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KMID : 0616120230540040153
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Korean Journal of Pharmacognosy
2023 Volume.54 No. 4 p.153 ~ p.159
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Effect of Eugenol on High-Fat Diet-Induced Obesity and Depression in Mice
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Jang Hyo-Min
Jeong Mi-Young
Kim Nam-Jae
Kim Dong-Hyun
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Abstract
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The excessive intake of a high-fat diet (HFD) leads to psychiatric disorders with obesity through gut dysbiosis. In the present study, we examined whether eugenol could alleviate obesity, depression, cognitive impairment, with neuroinflammation. Long-term exposure to high-fat diet induced depression and cognitive impairment with gut dysbiosis. However, oral administration of eugenol alleviated HFD-induced depression, but not obesity, and suppressed hippocampal tumor necrosis factor (TNF)-α expression in the hippocampus and colon-shortening and myeloperoxidase activity in the colon. Furthermore, eugenol treatment suppressed HFD-induced Proteobacteria and Actinobacteria populations in the gut microbiota. Eugenol increased corticosterone-suppressed brain-derived neurotropic factor (BDNF) expression in SH-SY5Y cells and decreased lipopolysaccharide-induced NF-κB activation in BV2 cells. These results suggest that eugenol may alleviate depression/anxiety by inducing gut microbiota-involved NF-κB activation-suppressed BDNF expression.
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KEYWORD
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Eugenol, High-fat diet, Psychiatric disorder, Gut microbiota, Inflammation
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